Jeremy L. Gilbert

Jeremy L. Gilbert

Research Professor

Biomedical & Chemical Engineering

Degree:

  • Ph.D., Carnegie Mellon University, 1987

Lab/Center Affiliation:

  • Syracuse Biomaterials Institute

Research Interests:

  • Biomaterials
  • Corrosion
  • Tribocorrosion
  • Bioelectrochemistry
  • Orthopedics
  • Biomechanics
  • Implant retrieval analysis
  • Failure analysis
  • Nanobiomaterials
  • Protein-surface interactions
  • Cell-surface Interactions
  • Self-reinforce composites
  • Smart medical devices
  • Modular orthopedic implants
  • Orthopedic Bone Cements
  • Surface Micromechanics

Current Research:

Dr. Gilbert’s research interests involve the study of Biomaterials Science with emphasis on the electrochemical behavior of medical alloys and their interaction with the biological system, the role of reduction reactions on biocompatibility, the mechanical-electrochemical interactions at metal-oxide-solution interfaces, and the development of novel mechanical, electrochemical, and polymeric test methodologies for orthopedic, spinal, dental and cardiovascular medical devices and biomaterials. He has worked in orthopedic bone cements, molecular orientation effects on amorphous polymeric materials, surface micro- and nanomechanics of polymers, metals, and biological tissues, use of atomic force microscopy to study the physics of passive metal-oxide film surfaces, polymer degradation mechanisms, adsorption phenomena on metallic biomaterials in the presence of electrochemical stimuli, and viscoelastic behavior of biomaterials. He has also published recent papers on tribocorrosion, implant retrieval and failure analysis, and performance testing of spinal and orthopedic implant designs. Dr. Gilbert has also studied novel coating technologies for wear and corrosion resistant surfaces, and on the impedance characteristics of metallic biomaterials.

Courses Taught:

  • Introductory Materials Science and Engineering
  • Undergraduate and graduate courses on
  • Advanced Biomechamics
  • Biomaterials and Medical Devices
  • Surfaces of Biomaterials

Honors:

  • Fellow of the American Institute for Medical and Biological Engineers
  • Fellow of Biomaterials Science and Engineering, College of Fellows of the International Union of Societies of Biomaterials Science and Engineering
  • Editor-in-Chief of the Journal of Biomedical Materials Research – Part B: Applied Biomaterials
  • Excellence in Graduate Education Award, Syracuse University, 2012.
  • Past-President, Society for Biomaterials
  • Cheney Senior International Faculty Fellow, Institute of Medical and Biological Engineering, Leeds University, 2015
  • Visiting Professor, Department of Materials Science and Engineering, University of Virginia, 2014-2015
  • Stevenson Lecturer, Syracuse University, 2015
  • Member, Medical Devices Committee, Food and Drug Administration

Selected Publications:

Peer Reviewed Papers

Haeri, M, Gilbert, JL, “The Voltage-Dependent Electrochemical Impedance Spectroscopy of CoCrMo Medical lloy Using Time-Domain Techniques: Generalized Cauchy-Lorentz, and KWW-Randles Functions Describing Non-Ideal Interfacial Behavior”, Corrosion Science, Feb. 2011, 53(2), pp 582-588.

Gilbert, JL “The Dangers of Adopting a Tissue-Engineering-Centric Agenda: A President’s Perspective”, J Biomed Mat Res, 2011, 96A(2): 273-274.

Swaminathan, V, Zeng, H, Lawrynowicz, D, Zhang, Z, Gilbert, JL, “Electrochemical Investigation of Chromium Oxide Coated Ti-6Al-4V and Co-Cr-Mo Alloy Substrates”, J Biomed Mat Res (B), 2011: 98B(2); 369-378.

Szkotak, R, Niepa, THP, Jawrani, N, Gilbert, JL, Jones, MB, Ren, D “Differential Gene Expression to Investigate the Effects of Low-level Electrochemical Currents on Bacillus Subtilis”, AMB Express, 2011, 1:39.

Gilbert, JL, Mali, SA, Urban, RM, Silverton, CD, Jacobs, JJ, “In-Vivo Oxide-Induced Stress Corrosion Cracking of Ti-6Al-4V in a Neck-Stem Modular Taper: Emergent Behavior in a New Mechanism of In-Vivo Corrosion”, J Biomed Mat Res – Part B: Applied Biomat, 2012: 100B(2); 584-594.

Swaminathan, V, Zeng, H, Lawrynowicz, D, Zhang, Z, Gilbert, JL, “Electrochemical investigation of chromium nanocarbide coated Ti-6Al-4V and Co-Cr-Mo alloy substrates”, Electrochemica Acta, 2012: 59;387-397.

Swaminathan, V, Gilbert, JL, “Fretting Corrosion of CoCrMo and Ti6Al4V Interfaces”, Biomaterials, 33 (2012), 5487-5503.

Niepa, THR, Gilbert, JL, Ren, D, “Controlling Pseudomonas Aeruginosa Persistent Biomaterials Infections by Weal Electrochemical Currents and Synergistic Effects with Tobramycin”, Biomaterials, 33 (2012), 7356-7265.

Haeri, M, Wollert, T, Langford, GM, Gilbert, JL, “Electrochemical Control of Cell Death by Reduction-Induced Intrinsic Apoptosis and Oxidation-Induced Necrosis on CoCrMo Alloy In-vitro”, Biomaterials, 33 (2012), 6295-6304.

Higgs GB, Hanzlik JA, MacDonald DW, Kane WM, Day JS, Klein GR, Parvizi J, Mont MA, Kraay MJ, Martell JM, Gilbert JL, Rimnac CM, Kurtz SN, “Method of Characterizing Fretting and Corrosion at the Various Taper Connections of Retrieved Modular Components from Metal-on-Metal Total Hip Arthroplasty”, Amer Soc for Testing and Mat, ASTM, Spec Tech Pub 1560 Metal-on-Metal Total Hip Replacement Devices, Eds., Kurtz, S, Greenwald, A, Mihalko, W, Lemmons, J, 2013, pp .

Higgs GB, Hanzlik JA, MacDonald DW, Gilbert JL, Rimnac CM, Kurtz SM “Is increased modularity associated with taper damage in metal-on-metal total hip arthroplasty devices?”, J. Arthroplasty, (2013) 29(8) Supp, 2-6.

Kurtz SM, Kocagoz SB, Hanzlik JA, Underwood RJ, Gilbert JL, MacDonald DW, Lee GC, Mont MA, Kraay MJ, Klein GR, Parvizi J, Rimnac C, “Do Ceramic Heads Reduce Taper Fretting in Hip Arthroplasty? A retrieval Study”, Clin Orthop and Rel Res (2013) 471:3270-3282.

Swaminathan V, Gilbert JL, “Potential and frequency effects on fretting corrosion of Ti6Al4V and CoCrMo surfaces”, J Biomed Mat Res – Part A, (2013) 101A(9):2602-2612.

Haeri M, Gilbert JL, “Study of cellular dynamics on polarized CoCrMo alloy using time-lapse live-cell imaging”, Acta Biomaterialia, April 2013, 9(11): 9220-9228.

Haeri M, Gilbert JL, “Voltage-controlled cellular behavior on polarized cpTi with varying surface oxide thickness”, Bioelectrochemistry, (2013); 94:53–60.

Sivan S, Kaul S, Gilbert JL, “The effect of cathodic electrochemical potential on cell viability: voltage threshold and time dependence”, J Biomed Mat Res, Part B, May, 2013, Vol 101, No 8: 1489-1497.

Kocagoz S, Underwood RJ, Sivan S, Gilbert JL, MacDonald DW, Day JS, Kurtz SM, “Does Taper Angle Clearance Influence Fretting and Corrosion Damage at the Head-Stem Interface?”, Seminars in Arthroplasty, 2014 24(4): 246-254.

Rodrigues DC, Gilbert JL, Bader RA, Hasenwinkel JM, “PMMA Brush-Containing Two-Solution Bone Cement: Preparation, Characterization, and Influence of Composition on Cement Properties”, J. Mat Sci: Mat and Med, 2014: 25;79-89.

Laurindo CAH, Torres RD, Mali SA, Gilbert JL, Soares P, “Incorporation of Ca and P on Anodized Titanium Surface: Effect of High Current Density”, Mat Sci and Eng, 2014;37:223-231.

Arnholt CM, MacDonald DW, Tohfafarosh M, Gilbert JL, Rimnac CM, Kurtz SM, “Mechanically Assisted Taper Corrosion in Modular TKA”, J. Arthroplasty, 2014, 29(9):205-208.

Porter DA, Urban RM, Jacobs JJ, Gilbert JL, Rodriguez JA, Cooper HJ, “Modern Tapers are More Flexible: A Mechanical Analysis of THA Trunnion Designs”, Clin Orthop and Rel Res, (2014) 472:3963-3970.

Gilbert JL, Sivan S, Liu Y, Kocagoz S, Arnholt C, Kurt SM, “Direct In Vivo Inflammatory Cell Induced Corrosion of CoCrMo Implant Surfaces”, J Biomed Mat Res A, (2015); 103(1): 211-223.

Ouellette ES, Gilbert JL¸ “Production and Characterization of Melt-Spun Poly(Ether Ether Ketone) Fibers for Biomedical Applications”, Polymer, Feb. 2015, DOI: 10.1016/j.polymer.2015.02.015.

Gilbert JL, Sivan S, Mali S, “Corrosion of Modular Tapers in Total Joint Replacements: A Critical Assessment of Design, Materials, Surfaces Structure, Mechanics, Electrochemistry and Biology”, ASTM Special Technical Publication on Implant Modularity, STP 1591, Eds. Greenwald, Kurtz, Lemons, Mihalko, ASTM Int 2015, in press.

Kurtz SM, MacDonald DW, Gilbert JL, Mont MA, Klein G, Chen A, Kraay M, Hamlin B, Rimnac CM, “Is Taper Fretting Corrosion a Threat to the Clinical Performance of Large-Diameter Hips with HXLPE Bearings?”, ASTM STP 1591, Ed. Greenwald, Lemons, Kurtz, Mihalko, ASTM International, W. Conshohocken, PA, 2015, in review.

Mali S, Gilbert JL, “Correlating Fretting Corrosion and Micromotions in Modular Tapers: Test Method Development and Assessment”, ASTM Special Technical Publication 1591 on Implant Modularity, Eds. Greenwald, Kurtz, Lemons, Mihalko, ASTM International, W. Conshohocken, PA, 2015, in press.

Clarken-Wright G, Parvizi J, Lee GC, Klein GR, Rimnac CM, Gilbert JL, Kurtz, SM, “Titanium alloy sleeves do not prevent fretting corrosion in modular THA”, J Arthroplasty, submitted, Sept, 2014

Higgs GB, MacDonald DW, Mihalko WM, Siskey RL, Gilbert JL, Rimnac CM, Kurtz SM, “Taper interface strength and its relationship with taper damage in retieved femoral components of total hip replacement devices: A pilot study”, ASTM STP 1591, Ed. Greenwald, Lemons, Kurtz, Mihalko, ASTM International, W. Conshohocken, PA, 2015, in review.

Kocagoz SB, Underwood RJ, MacDonald DW, Gilbert JL, Kurtz SM, “Ceramic Heads Decrease Metal Release Caused by Head-Taper Fretting and Corrosion”, submitted, Clin Orthop and Rel Res, Feb. 2015.

Arnholt C, Kocagoz SB, MacDonald DW, Gilbert JL, Malkani A, Klein G, Rimnac CM, Kurtz SM, “Corrosion and Damage Mechanisms in Retrieved Long-Term CoCr Femoral Components in TKA”, submitted, J Athroplasty , Feb. 2015.

Niepa THR, Snepenger LM, Wang H, Sivan S, Gilbert, JL, Jones MB, Ren D, “Sensitizing pseudomonas aeruginosa to anitbiotics by electrochemical disruption of membrane functions”, submitted, Biomaterials, June, 2015.

Gilbert JL, Mali SA, Liu Y, “Area-dependent impedance based voltage shifts during tribocorrosion of Ti-6Al-4V biomaterials: Theory and experiment”, submitted, IOP Surface Topography: Metrology and Properties, Special Topic Issue: Surfaces and interfaces in bioengineering systems”, submitted, July 2015.

Mali SA, Singh V, Gilbert JL,”Effect of mixed alloy combinations on fretting corrosion performance of spinal screw and rod implants”, submitted, J Biomed Mat Res – Part B: Applied Biomat, July 2015.

Kim J, Gilbert JL, “Cytotoxic Effect of Galvanically Coupled Magnesium-Titanium Particles”, submitted, Acta Biomat, Acta Biomat, in review, July 2015.

Gilbert JL, Pieri K, Sivan S, “Adverse Local Tissues Reactions Cause Corrosion of Ti-6Al-4V Hip Implant Components”, in review, July, 2015.

Morlock MM, Bunte D, Ettema H, Verheyen C, Hamberg A, Gilbert JL, “Primary hip replacement stem taper fracture due to corrosion – A case series of three patients”, Acta Orthopaedica, in review.

Book Chapters

Gilbert, JL, “Electrochemical Behaviour of Metals in the Biological Milieu”, Chapter 13, Comprehensive Biomaterials, Ed. Healy, Ducheyne, Kirkpatrick, Elsevier Press, 2011.

Gilbert, JL, Mali, S, “Medical Implant Corrosion: Electrochemistry at Metallic Biomaterial Surfaces”, Degradation of Implant Materials, Ed. N. Eliaz, Springer Press, in press, July 2012.

Gilbert JL, “Basic Science: Metals”, The Adult Hip, 3rd Edition, Raven Press, Ed. Callaghan, Rubash and Rosenberg, Lippencott-Raven Press, Vol. 1, Chapt. 8, 2015.

Gilbert JL, Sivan S, Mali SA, Kim J, Karker M, Kubacki GW, “Methods of Retrieval Analysis of Metallic Implants”, Implant Retrieval Analysis in Orthopedic Surgery, Ed. Kurtz, SM, Mihalko, WM, Springer, In review, 2015.

Gilbert JL, Kubacki GW, “Oxidative Stress, Inflammation and the Corrosion of Metallic Biomaterials: Corrosion Causes Biology and Biology Causes Corrosion”, Oxidative Stress and Biomaterials, Ed. TD Dziubla, DA Butterfield, Elsevier Press, in press, 2015, Chapt. 3.

M.S. Theses

Dipika Shetty, The Influence of Microparticles of Mg, Ti, and Mechanically Alloyed (50/50) MgTi on Mammalian Cell (MC3T3-E1) Viability, December 2011

Jin Guo – Interactions of bacterial biofilms with electrochemically active titanium surfaces undergoing reduction, August 2013

Tiantian Hui, How voltage and wear debris from Ti-6Al-4V interaction to affect cell viability during in vitro fretting corrosion, April 2014

Aarti Shenoy, The effect of roughness of the fretting corrosion behavior of 316L Stainless Steel surfaces

Ph.D. Theses

Morteza Haeri, Voltage Effects on Cells Cultured on Metallic Biomedical Implants, September 17, 2012

Viswanathan Swaminathan, Fundamental Studies of Fretting Corrosion of Orthopedic Implant Alloys, anticipated defense, December, 2012

Shiril Sivan, Electrochemical Aspects of Metallic Biocompatibility, February 23, 2014

Sachin Mali, Mechanically Assisted Corrosion Performance of Metallic Biomaterials: Implant Retrieval, Material Analyses and Device Testing, January 28, 2014