E coli on a petrie dish

Molecular Biotechnology

Molecular Biotechnology applies modern techniques of molecular biology in both fundamental and applied research. Examples of such powerful tools include DNA mutagenesis, DNA sequencing, RNA interference, stem cell technology, immunological methods, protein engineering, genomics, proteomics, bioinformatics, gene therapy and cloning techniques. These technologies offer exciting opportunities to understand and control complex systems at the molecular level for applications in healthcare, environmental protection, biofuel production and biosecurity. In Ren lab, for example, molecular biotechnology is being applied in a variety of research projects such as tracking bacterial cells using molecular cloning and bioimaging, sensor development for pathogen detection, novel technology for controlling drug resistant infections.

Representative publications

Jiachuan Pan, Ali Adem Bahar, Haseeba Syed, and Dacheng Ren. “Reverting antibiotic tolerance of Pseudomonas aeruginosa PAO1 persister cells by (Z)-4-bromo-5-(bromomethylene)-3-methylfuran-2(5H)-one”. PLoS ONE. 7(9): e45778. doi:10.1371/journal.pone.0045778. (2012).

Shuyu Hou, Huan Gu, Cassandra Smith and Dacheng Ren*, “Microtopographic patterns affect Escherichia coli biofilm formation on polydimethylsiloxane surfaces”. Langmuir. 27: 2686-2691 (2011).

Shuyu Hou, Zhigang Liu, Neville R. Kallenbach, and Dacheng Ren, ” Effects of Trp- and Arg-Containing Antimicrobial-Peptide Structure on Inhibition of Escherichia coli Planktonic Growth and Biofilm Formation”. Applied and Environmental Microbiology. 76: 1967-1974 (2010).

Miao Duo, Mi Zhang, Yan-Yeung Luk and Dacheng Ren, “Inhibition of Candida albicans Growth by Brominated Furanones”. Applied Microbiology and Biotechnology. 85: 1551-1563 (2010).

Shuyu Hou, Erik A. Button, Ricky Lei Wu, Yan-Yeung Luk and Dacheng Ren, “Prolonged Control of Patterned Biofilm Formation by Bio-inert Surface Chemistry”. Chemical Communication. 2009: 1207-1209.