Control of Bacterial Biofilm Formation
With up to 1000 times higher tolerance to antibiotics and disinfectants compared to their planktonic counterparts, biofilms of pathogenic bacteria cause chronic infections in humans with high mortality and morbidity. Such infections cause billions of dollars of losses and more than 45,000 deaths annually in the U.S. alone. With the efficacy of antibiotics being intrinsically limited, new approaches especially those with synergistic effects are desired. The Ren lab in BMCE department has board interests in biofilm control including the genetic basis of multidrug resistance, development of novel biofilm sensors, biofilm control through surface engineering and development of novel biofilm inhibitors.
Xi Chen, Mi Zhang, Chunhui Zhou, Neville R. Kallenbach and Dacheng Ren, “Control of bacterial persister cells by Trp/Arg antimicrobial peptides”. Applied and Environmental Microbiology. 77: 4878-4885 (2011).
Shuyu Hou, Zhigang Liu, Neville R. Kallenbach, and Dacheng Ren, ” Effects of Trp- and Arg-Containing Antimicrobial-Peptide Structure on Inhibition of Escherichia coli Planktonic Growth and Biofilm Formation”. Applied and Environmental Microbiology. 76: 1967-1974 (2010).
Miao Duo, Mi Zhang, Yan-Yeung Luk and Dacheng Ren, “Inhibition of Candida albicans Growth by Brominated Furanones”. Applied Microbiology and Biotechnology. 85: 1551-1563 (2010).
Erik A. Burton, Karen A. Simon, Shuyu Hou, Dacheng Ren, and Yan-Yeung Luk, “Molecular Gradients of Bio-inertness Reveal Mechanistic Difference between Mammalian Cell Adhesion and Bacterial Biofilm Formation”. Langmuir. 25: 1547-1553 (2009).
Shuyu Hou, Erik A. Burton, Ricky Lei Wu, Yan-Yeung Luk and Dacheng Ren, “Prolonged Control of Patterned Biofilm Formation by Bio-inert Surface Chemistry”. Chemical Communications. 2009, 1207-1209.
Jiachuan Pan and Dacheng Ren, “Quorum sensing inhibitors: a patent overview”. Expert Opinion On Therapeutic Patents (Invited Review). 19: 1581-1601 (2009).